PDRN

PDRN is a highly purified mix of DNA fragments, mainly derived from the milt of salmon species like chum salmon or rainbow trout.

How to use it

You can use PDRN skincare at any time of day and year, at any age, and during pregnancy. You'll find PDRN in creams, serums, and other skincare products. It works best in leave-on products, since longer contact with the skin makes it more effective.

Suitable for

Any skin type.

Things to know

PDRN molecules are quite large (up to 1500 kDa), so they struggle to get past the skin's protective barrier (the stratum corneum). This means standard creams mostly offer surface-level hydration and mild soothing.

The good news: research on PDRN in skincare shows medium-sized fractions like PDRN-850K can penetrate the epidermis and deliver more noticeable results.

Evidence

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Ingredient Overview

INCI name Sodium DNA or Hydrolyzed DNA

Function Skin and hair conditioning

CAS number -

Chemical formula -

Common use Face care

PDRN alternatives

Collagen Hyaluronic Acid

FAQ

1. Can you use PDRN with retinol?

Yes, PDRN and retinol can be combined, and there are even ready-made PDRN skincare products on the market that pair the two.

2. Does PDRN help with wrinkles?

Yes, fighting wrinkles is one of the key PDRN skincare benefits, backed by research—but mainly when it's injected.

3. Should I put moisturizer after PDRN?

Yes, that's a standard step in a skincare routine. Manufacturers usually recommend applying a moisturizer after the PDRN serum has been applied and absorbed.